I2B2/Shrine

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I2 offers the Informatics for Integrating Biology and the Bedside (i2b2) informatics tool, and the similar SHRINE (Shared Research Informatics Network) tool for the following two initiatives: Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS) and the Accrual for Clinical Trials (ACT).

I2 and BJC healthcare have collaborated to participate in these projects, funded by the Patient Centered Outcomes Research Institute (PCORI) for SCILHS and by the Clinical and Translational Science Award (CTSA) for ACT. Both SCILHS and ACT offer a clinical data research network, which permits query of clinical data resources across participating centers to identify cohorts of patients for study.

I2B2 is a comprehensive software and methodological framework that enables clinical researchers to accelerate the translation of genomic and “traditional” clinical findings into novel diagnostics, prognostics, and therapeutics. It provides a collaborative organizational and software infrastructure to allow basic researchers to leverage insights arising from clinical studies.

The goal of i2b2 is to develop the science and the engineering required to enable the clinical investigators of academic medical centers to conduct clinical research that is informed by state-of-the-art genomics and biomedical informatics.

SHRINE (Shared Health Research Information Network) is a system for enabling clinical researchers to solve the problem of identifying sufficient numbers of patients to include in their studies by querying across distributed hospital electronic medical record systems.

Shrine/I2B2 access is a level 1 service in the suite of Research Data Core access options offered by I2.

For more information, please contact I2.