Mackenzie Hofford, MD

Assistant Professor of Medicine
Division of General Medicine
School of Medicine

Medical Director of Informatics Core Services
Institute for Informatics (I2)

Mackenzie Hofford, MD, is interested in developing tools to help patients and physicians so that computers earn their place in exam rooms and at the bedside.


Originally from Rochester, NY, Dr. Hofford completed his undergraduate work at the University of Colorado at Boulder. After earning his degree he moved to Boston where he served as an AmeriCorps Member at Codman Square Health Center, a federally qualified health center in Dorchester. There he worked on projects supporting seniors of Haitian origin after the 2010 earthquake as well as several projects focused on improving the quality of preventative care.

Dr. Hofford attended medical school at the University of Rochester School of Medicine and Dentistry followed by a residency in Internal Medicine at Maine Medical Center in Portland. Dr. Hofford then went on to practice as a community based hospitalist at Central Maine Medical Center in Lewiston, Maine as well as providing primary care as a volunteer at a free clinic in Brunswick. While at Central Maine he developed an interest in clinical informatics. He completed a fellowship in clinical informatics at Washington University.

Dr. Hofford has an interest in improving healthcare quality through the use of big data and electronic health records. In addition to providing primary care he also serves as the medical director of core informatics services at the Institute for Informatics at Washington University. In that capacity he works with other faculty to leverage informatics tools to solve clinical and research problems.

Research Interests

  • Clinical Research Informatics
  • Clinical Data Structures
  • Machine Learning
  • Clinical Decision Support